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There are several considerations must be taken into account should you decide to implement cxs on your server:

Extensive scans on the server will use server resources and can impact performance. By its nature it is I/O intensive as it processes large numbers of files. The use of ClamAV can increase the load on the server significantly. These issues can be helped by the judicious use of the CLI options provided with cxs.
If you specifically configure the deletion or quarantine of suspicious file uploads via web scripts or FTP, it could cause considerable support issues where false-positives are detected.
Additionally, for FTP, if you configure the deletion or quarantine of suspicious file uploads it could potentially lead to data loss or corruption.
It could add significantly to the support of clients when investigating the reason for upload file deletions and configuring exceptions for false-positives.
It could lead to a deluge of emails being sent, if you have configured cxs to send them, if numerous false-positives are detected.